Perhaps needless to say, I am not a doctor or a medical professional so do not accept anything I write here as professional medical advice. Use your own judgment and advice of your doctors if you become ill.
Like most people, I am sheltering in place (or whatever your preferred term is for staying away from people) while the virus runs rampant through the United States. I doubt anything the current incompetent administration could have done would have prevented some severe disruption, but it seems to me clear that probably thousands of additional lives will be lost due to the missed opportunities to mobilize an effective response to this disease.
Until a vaccine is produced, I think the odds are good that you and I will get COVID-19 in one or more of waves that probably will pass through the population. If we are lucky, we will be ones with minor symptoms. If we are not, we will become seriously ill. One of the things I’ve been doing is looking at various alternatives for minimizing the effect of the virus.
First, regarding chloroquine or hydroxychloroquine. There’s a lot of attention on this drug because Dear Leader touted it at a news conference. So you will certainly hear a lot more about it. For the moment, I have this view:
“Whether hydroxychloroquine works in vivo is not proven for any virus, and in fact in randomised controlled trials against a number of viruses, including influenza, it doesn’t work at all,” says Douglas Richman, a virologist and infectious disease physician at the University of California, San Diego. “It’s my personal prejudice that this is also going to be the case with coronavirus.”
Another promising prescription drug is losartan. Losartan is an anti-hypertensive drug that has been in use for many years. There is conflicting information about whether potentially this drug could help or exacerbate the lung damage caused by the disease. The University of Minnesota is currently tied up in red tape trying to get a clinical trial underway. Chris Tignanelli is leading the clinical trials.
A study Inhibition of Viral Macrodomain of COVID-19 and Human TRPM2 by losartan discusses something that seems like a simulation but suggests: ” The inhibitory effect of losartan on PARP has been shown and it could interfere positively in several points (PARP, PARG- macrodomain and TRPM2) and decreases oxidative stress and apoptosis in COVID-19″.
Another article also discusses losartan and adds a number of supplements which are usually available over the counter. I say “usually” because I’ve noticed a run on vitamins and supplements in some stores since the virus has hit. These supplements include:
- Vitamin D
- N-acetylcysteine (NAC)
- NAD+ and niacin (+ L tryptophan)
An older review study on the SARS coronavirus finds potentially effective antiviral properties from curcumin: “The authors do present some evidence suggesting that the observed effect was due to binding of these compounds to the spike protein of SARS. In addition, some test phytochemicals mentioned in the paper inhibited SARS 3CL protease activity in enzyme assays”. Curcumin is found in the spice turmeric.
Finally, the jury seems to be out on whether NSAIDs, such as ibuprofen or naproxen, exacerbate lung damage. Some European countries were finding that people with the most severe symptoms had NSAIDs in their systems.